[MgSO4 therapy in severe pre-eclampsia/eclampsia]

Abstract

Corresponding to the newer literature and based on good own experiences lasting for four decades magnesium sulfate is put out as anticonvulsive drug of first choice in cases of severe preeclampsia and eclampsia. Especially the dosage is explained in connection with the classic schemes of Pritchard and Zuspan, in which a high concentration of magnesium in serum situated in therapeutic range is aspired to without additional sedatives. As standard dose initially 4 g MgSO4, followed by 2 g/h intravenously (in severe cases in the first hours 3 g/h) for continuing serum level applied by infusion pump are recommended. Dihydralazine as most used drug shall be applied by a second pump. Besides some newer results about the effects of magnesium sulfate on mother and child are mentioned.