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Comment
. 2011 Aug 3;14(2):149-50.
doi: 10.1016/j.cmet.2011.07.005.

MiRs with a sweet tooth

Anders M Näär  1
Affiliations
Comment

MiRs with a sweet tooth

Anders M Näär. Cell Metab. .

Abstract

MicroRNAs (miRNAs) have recently been found to be critical regulators of metabolic homeostasis. A study in Nature by Trajkovski et al. (2011) shows that the highly related miRNAs miR-103 and miR-107 modulate insulin sensitivity and glucose homeostasis in obese mice. These miRNAs might represent therapeutic targets to ameliorate obesity-associated insulin resistance.

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Figures

Figure 1
Figure 1. Model of miR-103/107 regulation of insulin sensitivity and glucose homeostasis
(A) miR-103/107 were found to be elevated in liver of obese mice. Data suggest that increased expression of miR-103/107 in liver and adipose tissues could contribute to insulin resistance and glucose intolerance. (B) Caveolin-1 (Cav1) was shown to be a direct target of miR-103/107 in adipocytes, and down-regulation of Cav1 expression by miR-103/107 resulted in decreased insulin (Ins) signaling through the insulin receptor (InsR) to AKT, and decreased glucose uptake.
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