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Meta-Analysis
. 2011 Sep;31(12):1301-14.
doi: 10.1177/0333102411415879. Epub 2011 Jul 29.

Migraine and mortality: a systematic review and meta-analysis

Markus Schürks  1 , Pamela M Rist, Robert E Shapiro, Tobias Kurth
Affiliations
Meta-Analysis

Migraine and mortality: a systematic review and meta-analysis

Markus Schürks et al. Cephalalgia. 2011 Sep.

Abstract

Objective: To evaluate the evidence on the association between migraine and mortality.

Methods: Systematic review and meta-analysis of studies investigating the association between any migraine (all forms of migraine collectively) or migraine subtypes (e.g. migraine with aura) and mortality published until March 2011.

Results: We identified ten cohort studies. Studies differed regarding the types of mortality investigated and only four presented aura-stratified results, limiting pooled analyses with regard to migraine subtypes and with regard to cause-specific mortality. For any migraine pooled analyses do not suggest an association with all-cause mortality (five studies; pooled relative risk (RR)=0.90, 95% confidence interval (CI) 0.71-1.16), cardiovascular disease mortality (CVD; six studies; pooled RR=1.09, 95% CI 0.89-1.32), or coronary heart disease mortality (CHD; three studies; pooled RR=0.95, 95% CI 0.57-1.60). Heterogeneity among studies is moderate to high. Two studies suggest that migraine with aura increases risk for CVD and CHD mortality.

Conclusion: This meta-analysis does not suggest that any migraine is associated with increased risk of mortality from all causes, CVD, or CHD. However, there is heterogeneity among studies and suggestion that migraine with aura increases CVD and CHD mortality. Given the high prevalence of migraine in the general population a definitive answer to the question of whether migraine or a subtype alters risk for mortality is of high public health importance and further targeted research implicated.

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Figures

Figure 1
Figure 1
Process of selecting studies
Figure 2
Figure 2
Relative risks for all-cause mortality among patients with any migraine from the individual studies and from the pooled analysis
Figure 3
Figure 3
Relative risks for CVD mortality among patients with any migraine from the individual studies and from the pooled analysis
Figure 4
Figure 4
Relative risks for CHD mortality among patients with any migraine from individual studies and from the pooled analysis
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References

    1. Lipton RB, Bigal ME. The epidemiology of migraine. Am J Med. 2005;118 Suppl 1:3S–10S. - PubMed
    1. Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol. 2006;5:148–157. - PMC - PubMed
    1. Silberstein SD. Migraine. Lancet. 2004;363:381–391. - PubMed
    1. Stewart WF, Ricci JA, Chee E, Morganstein D, Lipton R. Lost productive time and cost due to common pain conditions in the US workforce. JAMA. 2003;290:2443–2454. - PubMed
    1. Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27:193–210. - PubMed

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