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. 2011 Jan;27(1):67-73.

Intrathecal sufentanil versus fentanyl for lower limb surgeries - a randomized controlled trial

Poonam Motiani  1 , Sujata Chaudhary, Nitin Bahl, A K Sethi
Affiliations

Intrathecal sufentanil versus fentanyl for lower limb surgeries - a randomized controlled trial

Poonam Motiani et al. J Anaesthesiol Clin Pharmacol. 2011 Jan.

Retraction in

Abstract

Background: To compare the efficacy and safety of intrathecal sufentanil or fentanyl as adjuvants to hyperbaric bupivacaine in patients undergoing major orthopaedic lower limb surgeries in terms of onset and duration of sensory block, motor block and post-operative pain relief. PATIENTS #ENTITYSTARTX00026;

Methods: Ninety patients were recruited in this Prospective, randomized double blind study to receive either intrathecal sufentanil 5 μg (Group S), fentanyl 25 μg (Group F) or normal saline 0.5 ml (Group C) as adjuvants to 15 mg of 0.5% hyperbaric bupivacaine. The onset and duration of sensory and motor block were assessed intraoperatively. The pain scores were assessed postoperatively. Duration of complete and effective analgesia was recorded. The incidence of side effects such as nausea, vomiting, pruritus, shivering and PDPH was recorded.

Results: The Demographic data, hemodynamic and respiratory parameters were comparable in the three groups. There was a significantly earlier onset and prolonged duration of sensory block in the sufentanil and fentanyl groups. The duration of complete and effective analgesia were also significantly prolonged in the fentanyl and sufentanil groups. Pruritus was noticed in the study groups (Groups S&F).

Conclusions: Intrathecal sufentanil (5 μg) and fentanyl (25 μg), as adjuvants lead to an earlier onset and prolonged duration of sensory block. The duration of effective analgesia with intrathecal sufentanil and fentanyl as adjuvants to hyperbaric bupivacaine is longer than that of bupivacaine alone.

Keywords: Intrathecal adjuvant, Fentanyl; Sufentanil, Lower limb surgeries.

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Figures

Figure 1
Figure 1
Time to reach T-10 dermatomal level and maximum block height in the Groups S,F or C.
Figure 2
Figure 2
Time to two segment regression in the Groups S,F or C.
Figure 3
Figure 3
Comparison of the Sedation Scores in the Groups S,F and C.
Figure 4
Figure 4
Comparison of the VAS score in the Groups S, F or C.
Figure 5
Figure 5
Duration of analgesia in the Groups S,F or C. Incidence of Side Effects in the Groups S,F or C.
Figure 6
Figure 6
Incidence of Side Effects in the Groups S, F or C.
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