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. 2011 Jan;27(1):84-6.

Intrathecal catheterization and drug delivery in rats to compare the analgesic effects of morphine with ketorolac

Subrata Basu Ray  1 , Roman Saini, Rakesh Kumar
Affiliations

Intrathecal catheterization and drug delivery in rats to compare the analgesic effects of morphine with ketorolac

Subrata Basu Ray et al. J Anaesthesiol Clin Pharmacol. 2011 Jan.
No abstract available

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Figures

Figure 1
Figure 1
A rat after surgical implantation of the catheter in the intrathecal space (arrow)
Figure 2
Figure 2
To confirm the exact placement of the catheter, a contrast medium (lomeprol) was injected through the catheter. A = Without contrast B= With contrast. Arrow indicates the spread of the medium in the intrathecal space
Figure 3
Figure 3
Hargreaves Paw withdrawal apparatus
Figure 4
Figure 4
The analgesic effect of different doses of morphine as measured in the Hargreaves Paw Withdrawal Apparatus. Higher latency means greater analgesia.
Figure 5
Figure 5
The analgesic effect of ketorolac (300μg) as compared to morphine (30μg). Morphine induced analgesia is significantly higher than ketorolac between 15-90 min (*). Higher latency means greater analgesia. Statistical significance was set at P< 0.05.
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