Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:906154.
doi: 10.1155/2011/906154. Epub 2011 Jul 24.

Obesity and blood pressure in 17-year-old offspring of mothers with gestational diabetes: insights from the Jerusalem Perinatal Study

Meytal Avgil Tsadok  1 , Yechiel Friedlander, Ora Paltiel, Orly Manor, Vardiella Meiner, Hagit Hochner, Yael Sagy, Nir Sharon, Shoshanah Yazdgerdi, David Siscovick, Uriel Elchalal
Affiliations

Obesity and blood pressure in 17-year-old offspring of mothers with gestational diabetes: insights from the Jerusalem Perinatal Study

Meytal Avgil Tsadok et al. Exp Diabetes Res. 2011.

Abstract

Objective: Gestational diabetes mellitus (GDM) influences fetal development and offspring's metabolic risk. We evaluated this association in 17-year-old offspring adjusting for birth weight (BW) and prepregnancy maternal BMI (mBMI).

Study design: The JPS birth cohort contains extensive data on 92,408 births from 1964 to 1976. Offspring's BMI and blood pressure (BP) were obtained from military records. For a subcohort born between 1974 and 1976, prepregnancy mBMI was available. Offspring were classified as born to mothers with GDM (n = 293) or born to mothers without recorded GDM (n = 59,499).

Results: GDM offspring had higher mean BMI and systolic and diastolic BP compared to no-recorded-GDM offspring. After adjusting for BW, GDM remained significantly associated with offspring BMI and diastolic BP (β = 1.169 and 1.520, resp.). In the subcohort, when prepregnancy mBMI was entered to the models, it markedly attenuated the associations with GDM.

Conclusions: Maternal characteristics have long-term effects on cardiometabolic outcomes of their offspring aged 17 years.

PubMed Disclaimer

References

    1. Bateson P, Barker D, Clutton-Brock T, et al. Developmental plasticity and human health. Nature. 2004;430(6998):419–421. - PubMed
    1. Metzger BE, Buchanan TA, Coustan DR, et al. Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care. 2007;30(supplement 2):S251–S260. - PubMed
    1. Langer O, Yogev Y, Most O, Xenakis EMJ. Gestational diabetes: the consequences of not treating. American Journal of Obstetrics and Gynecology. 2005;192(4):989–997. - PubMed
    1. Weintrob N, Karp M, Moshe H. Short- and long-range complications in offspring of diabetic mothers. Journal of Diabetes and Its Complications. 1996;10(5):294–301. - PubMed
    1. Plagemann A, Harder T, Kohlhoff R, Rohde W, Dörner G. Overweight and obesity in infants of mothers with long-term insulin-dependent diabetes or gestational diabetes. International Journal of Obesity. 1997;21(6):451–456. - PubMed

LinkOut - more resources