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. 2011:2011:957901.
doi: 10.1155/2011/957901. Epub 2011 Jul 24.

Cardiac autonomic function correlates with arterial stiffness in the early stage of type 1 diabetes

S Liatis  1 , K Alexiadou, A Tsiakou, K Makrilakis, N Katsilambros, N Tentolouris
Affiliations

Cardiac autonomic function correlates with arterial stiffness in the early stage of type 1 diabetes

S Liatis et al. Exp Diabetes Res. 2011.

Abstract

Arterial stiffness is increased in type 1 diabetes (T1D), before any clinical complications of the disease are evident. The aim of the present paper was to investigate the association between cardiac autonomic function and arterial stiffness in a cohort of young T1D patients, without history of hypertension and any evidence of macrovascular and/or renal disease. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV). Cardiac autonomic function was assessed by the cardiovascular tests proposed by Ewing and Clarke. Patients with a high cardiac autonomic neuropathy score (≥4) had significantly higher PWV than those with a low score (0-1). A negative, heart rate-independent, correlation between PWV and heart rate variation during respiration was observed (r = -0.533, P < 0.001). In multivariable analysis, E/I index was the strongest correlate of PWV (β-coefficient = -0.326, P = 0.002). Cardiac parasympathetic function is a strong predictor of large arterial stiffness, in young T1D patients free of macrovascular and renal complications.

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Figure 1
Figure 1
Simple linear correlation between pulse wave velocity and E/I index.
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