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. 2011:7:735-9.
doi: 10.3762/bjoc.7.83. Epub 2011 May 31.

Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts

Affiliations

Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts

Hidekazu Oyamada et al. Beilstein J Org Chem. 2011.

Abstract

Continuous flow systems for hydrogenation using polysilane-supported palladium/alumina (Pd/(PSi-Al(2)O(3))) hybrid catalysts were developed. Our original Pd/(PSi-Al(2)O(3)) catalysts were used successfully in these systems and the hydrogenation of unsaturated C-C bonds and a nitro group, deprotection of a carbobenzyloxy (Cbz) group, and a dehalogenation reaction proceeded smoothly. The catalyst retained high activity for at least 8 h under neat conditions.

Keywords: flow chemistry; hydrogenation; palladium; polysilane; reduction.

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Figures

Figure 1
Figure 1
Schematic diagram of the continuous flow reactor (left) and the column top (right).
Scheme 1
Scheme 1
Hydrogenation of ethyl cinnamate.
Scheme 2
Scheme 2
Hydrogenation of trans-stilbene and trans-chalcone.
Scheme 3
Scheme 3
Hydrogenation of nitrobenzene and deprotection of the Cbz group.
Scheme 4
Scheme 4
Hydrogenation in water.

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