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. 2011 Aug 1;4(1):31.
doi: 10.1186/1756-8722-4-31.

High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma

Z L Wu  1 , Y Q Song, Y F Shi, J Zhu
Affiliations

High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma

Z L Wu et al. J Hematol Oncol. .

Abstract

Background: The purpose of the study was to investigate the expression and prognostic value of STAT3 in diffuse large B-cell lymphoma (DLBCL).

Methods: Seventy-four DLBCL patients from 2001 to 2007 were reviewed in the study. The STAT3 expression in their tumor tissues was examined using the immunohistochemistry (IHC) method, and evaluated for its association with clinicopathological parameters.

Results: Strong nuclear staining of STAT3 and phosphorylated-STAT3tyr705 (P-STAT3) were observed in 19 cases (25.7%) and 24 cases (32.4%), respectively, and the expression levels were highly consistent between them (P = 0.001). The high nuclear expression of STAT3 was more frequent in the non-germinal center B cell-like (non-GCB) DLBCL than that in the GCB subtype, but not reaching significance (P < 0.061). The high nuclear expression of STAT3 was found to be correlated with poor overall survival (OS) (P = 0.005). Multivariate Cox regression analysis showed that the STAT3 expression was an independent prognostic factor for DLBCL patients regardless of CHOP or R-CHOP regimen used as the first-line therapy.

Conclusion: STAT3 is more frequently expressed in non-GCB DLBCL than that in GCB subtype, and its strong nuclear expression is correlated with poor OS in DLBCL.

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Figures

Figure 1
Figure 1
STAT3 expression and P-STAT3 level in DLBCL (A) negative nuclear staining of STAT3, (B) negative nuclear staining of P-STAT3, (C) weak nuclear staining of STAT3, (D) weak nuclear staining of P-STAT3, (E) strong nuclear staining of STAT3, (F) strong nuclear staining of P-STAT3.
Figure 2
Figure 2
Kaplan-Meier curve of overall survival (OS) using STAT3 nuclear expression.
Figure 3
Figure 3
Kaplan-Meier curve of overall survival (OS) in patients with different treatment regimens using STAT3 nuclear expression. (A) Patients received the CHOP regimen; (B) Patients received the R-CHOP regimen.
See this image and copyright information in PMC

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