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. 1990;25(1):75-80.
doi: 10.1016/0531-5565(90)90012-q.

Aging and the response to Salmonella infection

S F Bradley  1 , C A Kauffman
Affiliations
Free article

Aging and the response to Salmonella infection

S F Bradley et al. Exp Gerontol. 1990.
Free article

Abstract

We investigated the effect of age on the ability of Fischer 344 rats to mount a febrile response and contain infection due to Salmonella typhimurium. Elderly (22-23 month), middle-aged (12-13 month) and young (2-3 month) rats were inoculated intraperitoneally with 1.5 X 10(6) organisms and the febrile response and liver and spleen bacterial counts were followed for 13 days. The elderly had a more sluggish febrile response and did not achieve as great a maximum temperature elevation as the young and middle-aged rats. Except for days 1 and 5, bacterial counts in liver and spleen were greater in the elderly rats than in young and middle-aged rats.

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