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. 2011 Oct;55(10):4912-4.
doi: 10.1128/AAC.00341-11. Epub 2011 Aug 1.

First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM

Julien Bador  1 , Lucie Amoureux, Jean-Marie Duez, Anthony Drabowicz, Eliane Siebor, Catherine Llanes, Catherine Neuwirth
Affiliations

First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM

Julien Bador et al. Antimicrob Agents Chemother. 2011 Oct.

Abstract

Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.

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Figures

Fig. 1.
Fig. 1.
Amino acid sequence similarities (%). MFP, membrane fusion protein (AxyA and homologues); RNDt, RND transporter (AxyB and homologues); OMP, outer membrane protein (AxyM and homologues); A.x.A8, A. xylosoxidans A8; A.p., Achromobacter piechaudii ATCC 43553; B.b., Bordetella bronchiseptica RB50; P.a., Pseudomonas aeruginosa PAO1.
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