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. 2011 May;55(3):242-6.
doi: 10.4103/0019-5049.82666.

A comparative study of the effect of clonidine and tramadol on post-spinal anaesthesia shivering

Usha Shukla  1 , Kiran Malhotra, T Prabhakar
Affiliations

A comparative study of the effect of clonidine and tramadol on post-spinal anaesthesia shivering

Usha Shukla et al. Indian J Anaesth. 2011 May.

Abstract

The aim of this study was to evaluate the efficacy, potency and side effects of clonidine as compared to tramadol in post-spinal anaesthesia shivering. In this prospective double-blind randomized controlled clinical trial, 80 American Society of Anaesthesiologists grade-l (ASAI) patients aged between 18 and 45 years scheduled for various surgical procedures under spinal anaesthesia, who developed shivering were selected.The patients were divided into two groups: Group C (n=40) comprised of patients who received clonidine 0.5mg/kg intravenously (IV) and group patients who received tramadol 0.5 mg/kg IV. Grade of shivering, disappearance of shivering, haemodynamics and side effects were observed at scheduled intervals. Disappearance of shivering was significantly earlier in group C (2.54±0.76) than in group T (5.01±1.02) (P=.0000001). Response rate to treatment in group C was higher (97.5%) than in group T (92.5%), but the difference was not significant. Nausea, vomiting and dizziness were found to be higher in group T (P=0.001, 0.005, 0.001, respectively), while the patients in group C were comparatively more sedated (sedation level, 2; group C, 25%). We conclude that clonidine gives better thermodynamics than tramadol, with fewer side effects.

Keywords: Clonidine; post-spinal anaesthesia shivering; tramadol.

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Conflict of interest statement

Conflict of Interest: None declared

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