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. 2010 May;2(3):190-4.
doi: 10.4103/0974-8490.65520.

The antihyperglycemic effect of aerial parts of Salvia splendens (scarlet sage) in streptozotocin-induced diabetic-rats

P Mahesh Kumar  1 , D Sasmal, Papiya Mitra Mazumder
Affiliations

The antihyperglycemic effect of aerial parts of Salvia splendens (scarlet sage) in streptozotocin-induced diabetic-rats

P Mahesh Kumar et al. Pharmacognosy Res. 2010 May.

Abstract

Salvia splendens (Labiatae) is widely used in Indian traditional medicine for the control of diabetes mellitus. In this study, the hypoglycemic effects produced by the acute and subacute administration of various extracts of S. splendens were investigated. Both the aqueous extract (SSAE) and the methanolic extract (SSME) from the aerial parts resulted in significant reductions of glycemia in streptozotocin (STZ)-induced diabetic rats after oral administration at a dose of 100 and 200 mg/kg, respectively. On oral administration, aqueous and methanolic extracts showed statistically significant (P < 0.001) effect by reducing the effect of glycemia in STZ-induced diabetic rats. These findings suggest the significant antihyperglycemic potential of the S. splendens extracts in ameliorating the diabetic conditions in diabetic rats. No significant effects were found in the normal rats.

Keywords: Acute and subacute antidiabetic studies; Salvia splendens; glibenclamide; streptozotocin-induced diabetic rats.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Acute hypoglycemic effect of Salvia splendens extracts on Streptozotocin induced diabetic rats
Figure 2
Figure 2
Sub acute hypoglycaemic effect of Salvia splendens extracts on Streptozotocin induced diabetic rats
See this image and copyright information in PMC

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