Review
doi: 10.1016/j.suponc.2011.04.004.
The optimal dose fractionation schema for malignant extradural spinal cord compression
Affiliations
- PMID: 21809513
- DOI: 10.1016/j.suponc.2011.04.004
Item in Clipboard
Review
The optimal dose fractionation schema for malignant extradural spinal cord compression
J Support Oncol.
2011 Jul-Aug.
Abstract
Malignant epidural spinal cord compression is a dreaded complication of malignancy. Fortunately, it does not happen very often. Estimating the prognosis is critical to achieving a balance between effective therapy and the burden of treatment. Treatment can be individualized by reviewing simple prognosis scales. For patients with a poor prognosis, a single fraction of 8 Gy is just as effective as multiple fractions and much more convenient. Surgery and radiation should be considered for patients with a more positive prognosis. For patients not getting surgery, enrollment in clinical trials of single vs. multiple fractions of radiation should be a priority.
Comment in
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Treatment of metastatic epidural spinal cord compression: the Goldilocks principle.J Support Oncol. 2011 Jul-Aug;9(4):125-6. doi: 10.1016/j.suponc.2011.04.005. J Support Oncol. 2011. PMID: 21809514 No abstract available.
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Does one size fit all? Is there a standard radiation dose for malignant spinal cord compression?J Support Oncol. 2011 Jul-Aug;9(4):127-8. doi: 10.1016/j.suponc.2011.04.006. J Support Oncol. 2011. PMID: 21809515 No abstract available.