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Multicenter Study
. 2011 Aug;53(4):369-72.
doi: 10.1093/cid/cir406.

Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa

Karen R Jacobson  1 , Danie Theron, Thomas C Victor, Elizabeth M Streicher, Robin M Warren, Megan B Murray
Affiliations
Multicenter Study

Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa

Karen R Jacobson et al. Clin Infect Dis. 2011 Aug.

Abstract

We report treatment outcomes from a retrospective cohort of patients with isoniazid-monoresistant tuberculosis in rural South Africa. Sixteen percent of patients had poor outcomes, 61% of whom progressed to multidrug-resistant tuberculosis. These data reveal the need for early identification and aggressive follow-up of isoniazid monoresistance to increase treatment success.

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References

    1. World Health Organization (WHO) Global tuberculosis control 2010. Available at: http://www.who.int/tb/publications/global_report/2010/en/index.html. Accessed 6 December 2010.
    1. Boehme C, Nabeta P, Hillemann D, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med. 2010;363:1005–15. - PMC - PubMed
    1. Mukherjee JS, Rich ML, Socci AR, et al. Programmes and principles in treatment of multidrug-resistant tuberculosis. Lancet. 2004;363:474–81. - PubMed
    1. Menzies D, Benedetti A, Paydar A, et al. Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: a systematic review and meta-analysis. PLoS Med. 2009;6:1–15. - PMC - PubMed
    1. Bang D, Andersen PH, Andersen AB, Thomsen VØ. Isoniazid-resistant tuberculosis in Denmark: mutations, transmission, and treatment outcome. J Infect. 2010;60:452–7. - PubMed

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