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Editorial
. 2011 Aug;96(8):1081-3.
doi: 10.3324/haematol.2011.048355.

Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome

Venetia Bigley, Matthew Collin
Editorial

Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome

Venetia Bigley et al. Haematologica. 2011 Aug.
No abstract available

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Figures

Figure 1.
Figure 1.
Evolution of DCML deficiency/MonoMAC. Schematic representation of the evolution of DCM deficiency beginning with an asymptomatic phase of cellular deficiency gradually evolving probably in the first decade of life. Infections begin in the second and third decade followed by increasing risk of carcinoma related to HPV, respiratory complications and finally overt leukemic transformation. BM cellularity declines and Flt-3 ligand probably rises in an inverse relationship until the proliferative phase of MDS occurs. This coincides with the acquisition of cytogenetic abnormalities and onset of cytopenias. MLP: multi-lymphoid progenitor; GMP: granulocyte-macrophage progenitor; HSC: hematopoietic stem cell; MEK megakaryoctye/erythroid progenitor.
See this image and copyright information in PMC

Comment on

References

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