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Comment
. 2011 Aug 2:7:520.
doi: 10.1038/msb.2011.53.

Suppressing variation in synthetic circuits

Eric Batchelor  1 , Galit Lahav
Affiliations
Comment

Suppressing variation in synthetic circuits

Eric Batchelor et al. Mol Syst Biol. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Type I incoherent feed-forward loops (I1-FFLs) make biological output insensitive to DNA copy number. Transient transfection generates a broad distribution of the number of transfected plasmids (red circles), causing a broad range of circuit input. (A) I1-FFLs suppress this variation and generate a robust output. (B) Transcriptional autoregulatory motifs (tAMs) generate a graded output that is proportional to the number of plasmids in each cell.
See this image and copyright information in PMC

Comment on

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