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. 1979 Jan;306(1):101-3.
doi: 10.1007/BF00515602.

Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries

K Schrör, P Rösen

Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries

K Schrör et al. Naunyn Schmiedebergs Arch Pharmacol. 1979 Jan.

Abstract

The effects of prostacyclin (PGI2) on vascular tension and cAMP content were measured in isolated bovine coronary artery strips. 3 nM PGI2 did not alter the tension but diminished the cAMP content by 56% of the control level (P less than 0.005). 30 and 300 nM PGI2 diminished the tension and further reduced the cAMP content, which amounted to only 5% of the control at 300 nM PGI2. These results are in contrast to the increase in cAMP level by PGI2 in blood platelets and might indicate a different mechanism of action of PGI2 in platelets and vascular tissue.

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References

    1. Life Sci I. 1972 Sep 1;11(17):817-24 - PubMed
    1. J Physiol. 1978 Nov;284:106P-107P - PubMed
    1. Eur J Pharmacol. 1978 Jan 1;47(1):103-14 - PubMed
    1. Prostaglandins. 1977 Jan;13(1):3-15 - PubMed
    1. Am J Physiol. 1976 May;230(5):1239-43 - PubMed