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. 2011 Jul;34(7):1201-8.
doi: 10.1007/s12272-011-0719-6. Epub 2011 Aug 3.

The antidiabetic effect of ginsenoside Rb2 via activation of AMPK

Kyoung-Tae Lee  1 , Tae Woo Jung, Hak-Ju Lee, Seul-Gi Kim, Yu-Su Shin, Wan-Kyunn Whang
Affiliations

The antidiabetic effect of ginsenoside Rb2 via activation of AMPK

Kyoung-Tae Lee et al. Arch Pharm Res. 2011 Jul.

Abstract

Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.

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