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. 2011;3 Suppl 1(Suppl 1):11-7.
doi: 10.2147/CLEP.S20613. Epub 2011 Jul 20.

Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009

Morten Høyer  1 , Rune Erichsen, Per Gandrup, Mette Nørgaard, Jacob Bonde Jacobsen
Affiliations

Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009

Morten Høyer et al. Clin Epidemiol. 2011.

Abstract

Objective: In Denmark, the strategy for treatment of cancer with metastases to the liver has changed dramatically during the period 1998 to 2009, when multidisciplinary care and a number of new treatments were introduced. We therefore examined the changes in survival in Danish patients with colorectal carcinoma (CRC) or other solid tumors (non-CRC) who had liver metastases at time of diagnosis.

Study design and methods: We included patients diagnosed with liver metastases synchronous with a primary cancer (ie, a solid cancer diagnosed at the same date or within 60 days after liver metastasis diagnosis) during the period 1998 to 2009 identified through the Danish National Registry of Patients. We followed those who survived for more than 60 days in a survival analysis (n = 1021). Survival and mortality rate ratio (MRR) at 1, 3, and 5 years stratified by year of diagnosis were estimated using Cox proportional hazards regression analysis.

Results: In the total study population of 1021 patients, 541 patients had a primary CRC and 480 patients non-CRC. Overall, the 5-year survival improved from 3% (95% confidence interval [CI]: 1%-6%) in 1998-2000 to 10% (95% CI: 6%-14%) in 2007 to 2009 (predicted value). The 5-year survival for CRC-patients improved from 1% (95% CI: 0%-5%) to 11% (95% CI: 6%-18%) whereas survival for non-CRC patients only increased from 5% (95% CI: 1%-10%) to 8% (95% CI: 4%-14%).

Conclusion: We observed improved survival in patients with liver metastases in a time period characterized by introduction of a structured multidisciplinary care and improved treatment options. The survival gain was most prominent for CRC-patients.

Keywords: colorectal cancer; liver metastases; noncolorectal cancer; survival improvement.

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Figures

Figure 1
Figure 1
Age distribution of the total cohort of 1021 patients diagnosed with liver metastases, Denmark 1998 to 2009.
Figure 2
Figure 2
Crude survival of A) the total patient cohort with synchronous liver metastases (n = 1021), B) the cohort of colorectal cancer (CRC)-patients with synchronous liver metastases (n = 541), and C) the cohort of non-CRC patients with synchronous liver metastases (n = 480), stratified by period of diagnosis.
See this image and copyright information in PMC

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