Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Oct 7;9(19):6496-7.
doi: 10.1039/c1ob06041d. Epub 2011 Aug 4.

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Francesco Ravalico  1 , Ivano Messina, M Victoria Berberian, Stuart L James, Marie E Migaud, Joseph S Vyle
Affiliations

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Francesco Ravalico et al. Org Biomol Chem. .

Abstract

Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.

PubMed Disclaimer

Publication types

LinkOut - more resources