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Comment
. 2011 Aug 5;43(3):323-5.
doi: 10.1016/j.molcel.2011.07.007.

The Ripoptosome: death decision in the cytosol

Mathieu J M Bertrand  1 , Peter Vandenabeele
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Free article
Comment

The Ripoptosome: death decision in the cytosol

Mathieu J M Bertrand et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Tenev et al. and Feoktistova et al. describe the Ripoptosome, a cytosolic death-inducing RIP1-, FADD-, and caspase-8-containing complex that spontaneously assembles upon cIAP depletion, challenging the view that such complexes exclusively originate from receptor activation.

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