A simple code for installing hepatocyte function
- PMID: 21816357
- DOI: 10.1016/j.stem.2011.07.009
A simple code for installing hepatocyte function
Abstract
Forced lineage conversion of accessible cell types can supply scarce or inaccessible cells for research and therapy. Two papers in Nature now report the identification of transcription factors sufficient for inducing therapeutically effective hepatocyte function in fibroblasts (Huang et al., 2011; Sekiya and Suzuki, 2011).
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors.Nature. 2011 May 11;475(7356):386-9. doi: 10.1038/nature10116. Nature. 2011. PMID: 21562492
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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.Nature. 2011 Jun 29;475(7356):390-3. doi: 10.1038/nature10263. Nature. 2011. PMID: 21716291
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