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. 1979 Jan;76(1):442-6.
doi: 10.1073/pnas.76.1.442.

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene

R Finberg, H L Weiner, B N Fields, B Benacerraf, S J Burakoff

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene

R Finberg et al. Proc Natl Acad Sci U S A. 1979 Jan.

Abstract

Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.

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References

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