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. 2011;9(7):1210-1219.
doi: 10.3390/md9071210. Epub 2011 Jul 7.

A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus

Charline Abed  1   2 , Nathalie Legrave  1 , Maeva Dufies  3 , Guillaume Robert  3 , Vincent Guérineau  4 , Jean Vacelet  2 , Patrick Auberger  3 , Philippe Amade  1 , Mohamed Mehiri  1
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A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus

Charline Abed et al. Mar Drugs. 2011.

Abstract

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.

Keywords: Sarcotragus spinosulus; bioactivity; hydroxylated polyprenylhydroquinone; marine natural products; sponges.

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Figures

Figure 1
Figure 1
Structure of compounds 1, 2, and 3.
Figure 2
Figure 2
Sarcotragus spinosulus.
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