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. 2012:2012:505197.
doi: 10.4061/2012/505197. Epub 2011 Jun 9.

Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury

Laura E White  1 , Heitham T Hassoun
Affiliations

Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury

Laura E White et al. Int J Nephrol. 2012.

Abstract

Acute kidney injury (AKI) is a common complication during inpatient hospitalization, and clinical outcomes remain poor despite advancements in renal replacement therapy. AKI in the setting of multiple organ failure (MOF) remains a formidable challenge to clinicians and incurs an unacceptably high mortality rate. Kidney ischemia-reperfusion injury (IRI) incites a proinflammatory cascade and releases cellular and soluble mediators with systemic implications for remote organ injury. Evidence from preclinical models cites mechanisms of organ crosstalk during ischemic AKI including the expression of cellular adhesion molecules, lymphocyte trafficking, release of proinflammatory cytokines and chemokines, and modification of the host innate and adaptive immune response systems. In this paper, the influence of kidney IRI on systemic inflammation and distant organ injury will be examined. Recent experimental data and evolving concepts of organ crosstalk during ischemic AKI will also be discussed in detail.

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Figures

Figure 1
Figure 1
AKI and organ crosstalk. AKI induces remote organ injury in the heart, brain, lungs, liver, and gut involving multiple inflammatory pathways, including increased expression of soluble proinflammatory mediators, innate and adaptive immunity, cellular apoptosis, physiologic derangements and genomic changes.
Figure 2
Figure 2
Pathological Axis between AKI and ALI. AKI induces pathophysiologic effects on the lung via cellular and soluble mediators. ALI, in turn, exacerbates kidney dysfunction through metabolic and biochemical derangements.
See this image and copyright information in PMC

References

    1. Levy EM, Viscoli CM, Horwitz RI. The effect of acute renal failure on mortality: a cohort analysis. Journal of American Medical Association . 1996;275(19):1489–1494. . - PubMed
    1. Metnitz PGH, Krenn CG, Steltzer H, et al. Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Critical Care Medicine . 2002;30(9):2051–2058. . - PubMed
    1. Bass HE, Greenberg D, Singer E, Miller MA. Pulmonary changes in uremia. Journal of American Medical Association . 1952;148:724–726. . - PubMed
    1. Back MR, Bandyk M, Bradner M, et al. Critical analysis of outcome determinants affecting repair of intact aneurysms involving the visceral aorta. Annals of Vascular Surgery . 2005;19(5):648–656. . - PubMed
    1. Kashyap VS, Cambria RP, Davison JK, L'Italien GJ. Renal failure after thoracoabdominal aortic surgery. Journal of Vascular Surgery . 1997;26(6):949–955. . - PubMed

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