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. 2011 Sep 28;47(36):10037-9.
doi: 10.1039/c1cc13665h. Epub 2011 Aug 8.

Total synthesis of (-)-nakadomarin A

Andrew F Kyle  1 , Pavol Jakubec, Dane M Cockfield, Ed Cleator, John Skidmore, Darren J Dixon
Affiliations

Total synthesis of (-)-nakadomarin A

Andrew F Kyle et al. Chem Commun (Camb). .

Abstract

A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furan N-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (-)-nakadomarin A.

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