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. 1990 Mar;28(3):596-9.
doi: 10.1128/jcm.28.3.596-599.1990.

Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults

J J Treanor  1 , F K Roth, R F Betts
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Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults

J J Treanor et al. J Clin Microbiol. 1990 Mar.

Erratum in

  • J Clin Microbiol 1990 Jun;28(6):1491

Abstract

To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-adapted vaccines were immunogenic in seropositive adults. In addition, individuals receiving cold-adapted vaccines had lower rates of virus shedding and illness following challenge with wild-type influenza virus than did unvaccinated seropositive volunteers.

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References

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