Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Sep;16(6):517-24.
doi: 10.3109/1354750X.2011.604133. Epub 2011 Aug 9.

Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children

Linda H Nie  1 , Robert O Wright, David C Bellinger, Javed Hussain, Chitra Amarasiriwardena, David R Chettle, Ana Pejović-Milić, Alan Woolf, Michael Shannon
Affiliations

Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children

Linda H Nie et al. Biomarkers. 2011 Sep.

Abstract

Objective: To find the best lead exposure assessment marker for children.

Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level.

Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score.

Conclusion: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Current blood lead level versus CBLI 1. Correlation coefficient: 0.600 (p = 0.067). (Outlier ID #54 removed). The two curved lines represent the 95% confidence interval.
Figure 2
Figure 2
Full-scale IQ score versus CBLI 1. Correlation coefficient: 0.823 (p = 0.006). (Outlier ID #54 removed). The two curved lines represent the 95% confidence interval.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Barry PS, Mossman DB. Lead concentrations in human tissues. Br j Ind Med. 1970;27:339–351. - PMC - PubMed
    1. Brito JA, McNeill FE, Webber CE, Wells S, Richard N, Carvalho ML, Chettle DR. Evaluation of a novel structural model to describe the endogenous release of lead from bone. j Environ Monit. 2002;4:194–201. - PubMed
    1. Farias P, Echavarria M, Hernandez-Avila M, Villanueva C, Amarasiriwardena C, Hernandez L, Aro A, Hu H. Bone, blood and semen lead in men with environmental and moderate occupational exposure. Int j Environ Health Res. 2005;15:21–31. - PubMed
    1. Fleming DE, Boulay D, Richard NS, Robin JP, Gordon CL, Webber CE, Chettle DR. Accumulated body burden and endogenous release of lead in employees of a lead smelter. Environ Health Perspect. 1997;105:224–233. - PMC - PubMed
    1. Goldman RH, White R, Kales SN, Hu H. Lead poisoning from mobilization of bone stores during thyrotoxicosis. Am j Ind Med. 1994;25:417–424. - PubMed

Publication types

MeSH terms