Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 May 1;64(6):523-30.
doi: 10.1016/j.addr.2011.07.003. Epub 2011 Jul 30.

Gut-associated lymphoid tissues for the development of oral vaccines

Jun Kunisawa  1 , Yosuke Kurashima, Hiroshi Kiyono
Affiliations
Review

Gut-associated lymphoid tissues for the development of oral vaccines

Jun Kunisawa et al. Adv Drug Deliv Rev. .

Abstract

Oral vaccine has been considered to be a prospective vaccine against many pathogens especially invading across gastrointestinal tracts. One key element of oral vaccine is targeting efficient delivery of antigen to gut-associated lymphoid tissue (GALT), the inductive site in the intestine where antigen-specific immune responses are initiated. Various chemical and biological antigen delivery systems have been developed and some are in clinical trials. In this review, we describe the immunological features of GALT and the current status of antigen delivery system candidates for successful oral vaccine.

PubMed Disclaimer

Publication types