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Comment
. 2011 Aug 15;17(16):5217-9.
doi: 10.1158/1078-0432.CCR-11-1219. Epub 2011 Aug 9.

Overcoming antiangiogenic resistance

James C Yao  1 , Alexandria Phan
Affiliations
Comment

Overcoming antiangiogenic resistance

James C Yao et al. Clin Cancer Res. .

Abstract

The success of drugs targeting angiogenesis is tempered by the transient duration of disease control and modest survival improvement. The very hypoxic stress produced by successful therapy may lead to upregulation of multiple pathways that promote angiogenesis and invasive behavior. Overcoming this evasive resistance may further improve outcome.

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