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. 2011 Aug 9;16(8):6747-57.
doi: 10.3390/molecules16086747.

Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds

Toshiki Nakano  1 , Yusuke Yagi, Mizuki Miyahara, Akio Kaminura, Motoi Kawatsura, Toshiyuki Itoh
Affiliations

Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds

Toshiki Nakano et al. Molecules. .

Abstract

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Multi-useful chiral building block for the synthesis of non natural amino acids and amino alcohols.
Scheme 2
Scheme 2
Kinetic resolution of (±)-1 using an enzymatic reaction.
Scheme 3
Scheme 3
Protocol of preparation of chiral 1 using “low-temperature lipase-catalyzed transesterification”.
Scheme 4
Scheme 4
2-methyl-2-nitrobut-3-en-ol (±)-1.
Scheme 5
Scheme 5
(R)-2-amino-2-methyl-4-(4-(heptyloxy)phenyl)butan-1-ol (5).
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