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. 2010 Jul;2(3):189-96.
doi: 10.4103/0975-7406.68500.

Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses

Sudha Rana  1 , Raj Kumar, Sarwat Sultana, Rakesh Kumar Sharma
Affiliations

Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses

Sudha Rana et al. J Pharm Bioallied Sci. 2010 Jul.

Abstract

Radiation incident involving living organisms is an uncommon but a very serious situation. The first step in medical management including triage is high-throughput assessment of the radiation dose received. Radiation exposure levels can be assessed from viability of cells, cellular organelles such as chromosome and different intermediate metabolites. Oxidative damages by ionizing radiation result in carcinogenesis, lowering of the immune response and, ultimately, damage to the hematopoietic system, gastrointestinal system and central nervous system. Biodosimetry is based on the measurement of the radiation-induced changes, which can correlate them with the absorbed dose. Radiation biomarkers such as chromosome aberration are most widely used. Serum enzymes such as serum amylase and diamine oxidase are the most promising biodosimeters. The level of gene expression and protein are also good biomarkers of radiation.

Keywords: Biodosimetry; biomarkers; gene expression; oxidative damages; radiation accident; serum amylase.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Radiation responsive biomarkers
Figure 2
Figure 2
Cellular responses to ionizing radiation
See this image and copyright information in PMC

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