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. 2009:2009:bcr01.2009.1449.
doi: 10.1136/bcr.01.2009.1449. Epub 2009 Aug 10.

Complete remission of a relapsing adult T cell leukaemia following treatment of a secondary acute promyelocytic leukaemia: towards a reappraisal of arsenic trioxide and all-transretinoic acid?

Marie-Olivia Chandesris  1 , David Ghez, Caroline Besson, Felipe Suarez, Richard Delarue, Marie-Thérèse Rubio, Ali Bazarbachi, Bruno Varet, Olivier Hermine
Affiliations

Complete remission of a relapsing adult T cell leukaemia following treatment of a secondary acute promyelocytic leukaemia: towards a reappraisal of arsenic trioxide and all-transretinoic acid?

Marie-Olivia Chandesris et al. BMJ Case Rep. 2009.

Abstract

Despite improvements in therapeutic options, human T cell lymphotropic virus type 1 (HTLV-1)-related adult T cell leukaemia/lymphoma (ATLL) has a dismal prognosis. The present report concerns the case of a multirelapsing ATLL that reached a complete remission following the treatment of a secondary acute promyelocytic leukaemia with cytarabine, anthracyclin, all-transretinoic acid and arsenic trioxide. This unexpected result with a multitreated/chemorefractory disease led us to reconsider the potential therapeutic benefits of arsenic trioxide, which has demonstrated efficacy against ATLL cells.

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