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Multicenter Study
. 2011 Aug 10;15(4):R192.
doi: 10.1186/cc10349.

O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management?

Filip de Somer  1 , John W Mulholland, Megan R Bryan, Tommaso Aloisio, Guido J Van Nooten, Marco Ranucci
Affiliations
Multicenter Study

O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management?

Filip de Somer et al. Crit Care. .

Abstract

Introduction: Acute kidney injury (AKI) is common after cardiac operations. There are different risk factors or determinants of AKI, and some are related to cardiopulmonary bypass (CPB). In this study, we explored the association between metabolic parameters (oxygen delivery (DO2) and carbon dioxide production (VCO2)) during CPB with postoperative AKI.

Methods: We conducted a retrospective analysis of prospectively collected data at two different institutions. The study population included 359 adult patients. The DO2 and VCO2 levels of each patient were monitored during CPB. Outcome variables were related to kidney function (peak postoperative serum creatinine increase and AKI stage 1 or 2). The experimental hypothesis was that nadir DO2 values and nadir DO2/VCO2 ratios during CPB would be independent predictors of AKI. Multivariable logistic regression models were built to detect the independent predictors of AKI and any kind of kidney function damage.

Results: A nadir DO2 level < 262 mL/minute/m2 and a nadir DO2/VCO2 ratio < 5.3 were independently associated with AKI within a model including EuroSCORE and CPB duration. Patients with nadir DO2 levels and nadir DO2/VCO2 ratios below the identified cutoff values during CPB had a significantly higher rate of AKI stage 2 (odds ratios 3.1 and 2.9, respectively). The negative predictive power of both variables exceeded 90%. The most accurate predictor of AKI stage 2 postoperative status was the nadir DO2 level.

Conclusions: The nadir DO2 level during CPB is independently associated with postoperative AKI. The measurement of VCO2-related variables does not add accuracy to the AKI prediction. Since DO2 during CPB is a modifiable factor (through pump flow adjustments), this study generates the hypothesis that goal-directed perfusion management aimed at maintaining the DO2 level above the identified critical value might limit the incidence of postoperative AKI.

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Figures

Figure 1
Figure 1
Graph showing acute kidney injury rate according to decile distribution of nadir oxygen delivery (DO2) level during cardiopulmonary bypass (CPB).
Figure 2
Figure 2
Acute kidney injury rate according to decile distribution of nadir DO2/VCO2 ratio during CPB.
Figure 3
Figure 3
Receiver operating characteristic curves for acute kidney injury stage 2 rate prediction based on nadir DO2 level, nadir DO2/VCO2 ratio and nadir hematocrit (HCT) level.
Figure 4
Figure 4
Acute kidney injury rates in patient groups according to the critical values of DO2, DO2/VCO2 ratio and hematocrit, with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).
See this image and copyright information in PMC

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