Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Sep;40(6):393-6.
doi: 10.1259/dmfr/51850495.

Primary xanthoma of the mandible

F M de Moraes Ramos-Perez  1 , J M de Pádua, Y T C Silva-Sousa, O P de Almeida, Danyel Elias da Cruz Perez
Affiliations
Case Reports

Primary xanthoma of the mandible

F M de Moraes Ramos-Perez et al. Dentomaxillofac Radiol. 2011 Sep.

Abstract

Bone xanthomas are rare and are usually are associated with endocrine or metabolic diseases, mainly lipid disorders. In the absence of systemic diseases, the lesion is called a primary xanthoma. Primary mandibular xanthomas are extremely rare. The aim of this report is to describe the clinical and radiographic findings of a primary mandibular xanthoma, discussing the epidemiological features, pathogenesis and differential diagnosis. A 25-year-old man was referred for evaluation of a left mandibular lesion detected in a routine radiographic exam. Radiographically, there was a diffuse, unilocular and radiolucent lesion, with irregular margins located adjacent to the surface from the distal root of the left mandibular third molar. The lesion was excised under local anaesthesia. Microscopically, there were several cells with a foamy and granular cytoplasm and central small, round nuclei, similar to xanthomatous macrophages. No lipid disorders were diagnosed. According to these features, the diagnosis of primary mandibular xanthoma was established. In conclusion, xanthomas of the jaws are rare and all seem to be primary and occur exclusively in the mandible.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Panoramic radiograph reveals a diffuse, unilocular and radiolucent lesion, with irregular margins, located adjacent to the surface from the distal root of the left mandibular third molar (arrow)
Figure 2
Figure 2
Close view of the lesion in the panoramic radiograph
Figure 3
Figure 3
Numerous cells with a foamy and granular cytoplasm and central small and round nuclei (arrows), similar to xanthomatous macrophages (haematoxylin and eosin stain, original magnification, ×200)
Figure 4
Figure 4
Xanthomatous cells presenting strong positivity for CD-68 (arrows) (streptavidin-biotin-peroxidase method, ×200)
See this image and copyright information in PMC

References

    1. Marqués Mateo M, Puche Torres M, Miragall Alba L, Iglesias Gimilio ME, Pascual Gil JV. Primary mandibular bone xanthoma. A case report. Int J Oral Maxillofac Surg 2004;33:806–807 - PubMed
    1. Matoba M, Tonami H, Kuginuki M, Yamamoto I, Akai T, Iizuka H. CT and MRI findings of xanthoma in the orbitofrontal region. Radiat Med 2004;22:116–119 - PubMed
    1. Kuroiwa T, Ohta T, Tsutsumi A. Xanthoma of the temporal bone: case report. Neurosurgery 2000;46:996–998 - PubMed
    1. Bertoni F, Unni KK, McLeod RA, Sim FH. Xanthoma of bone. Am J Clin Pathol 1988;90:377–384 - PubMed
    1. Boisgard S, Bringer O, Aufauvre B, Joudet T, Kemeny JL, Michel JL, et al. Intraosseous xanthoma without lipid disorders. Case-report and literature review. Joint Bone Spine 2000;67:71–74 - PubMed

Publication types