Comment
doi: 10.1126/scitranslmed.3002822.
Cancer drug discovery faces the FACT
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- PMID: 21832237
- DOI: 10.1126/scitranslmed.3002822
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Comment
Cancer drug discovery faces the FACT
Sci Transl Med.
.
Abstract
In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules-curaxins-that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.
Comment on
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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.Sci Transl Med. 2011 Aug 10;3(95):95ra74. doi: 10.1126/scitranslmed.3002530. Sci Transl Med. 2011. PMID: 21832239 Free PMC article.
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