Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov 16:1:136.
doi: 10.3389/fphar.2010.00136. eCollection 2010.

Bladder dysfunction in diabetes mellitus

Affiliations

Bladder dysfunction in diabetes mellitus

Saeid Golbidi et al. Front Pharmacol. .

Abstract

Diabetic cystopathy is a well-recognized complication of diabetes mellitus, which usually develops in middle-aged or elderly patients with long-standing and poorly controlled disease. It may have broad spectrum clinical presentations. Patients may be asymptomatic, or have a wide variety of voiding complaints from overactive bladder and urge incontinence to decreased bladder sensation and overflow incontinence. This review focuses on pathophysiological mechanisms responsible for urologic complications of diabetes and emphasizing on recent developments in our understanding of this condition. We also tried to shed some light on therapeutic modalities like behavioral, pharmacological, and surgical approaches.

Keywords: cystopathy; diabetes; incontinence; neurogenic bladder.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Treatment levels for diabetic bladder.

References

    1. Abrams P., Andersson K. E., Buccafusco J. J., Chapple C., de Groat W. C., Fryer A. D., Kay G., Laties A., Nathanson N. M., Pasricha P. J., Wein A. J. (2006). Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Br. J. Pharmacol. 148, 565–578 - PMC - PubMed
    1. Apodaca G. (2004). The uroepithelium: not just a passive barrier. Traffic 5, 117–12810.1046/j.1600-0854.2003.00156.x - DOI - PubMed
    1. Apodaca G., Kiss S., Ruiz W., Meyers S., Zeidel M., Birder L. (2003). Disruption of bladder epithelium barrier function after spinal cord injury. Am. J. Physiol. Renal Physiol. 284, F966–F976 - PubMed
    1. Beshay E., Carrier S. (2004). Oxidative stress plays a role in diabetes-induced bladder dysfunction in a rat model. Urology 64, 1062–106710.1016/j.urology.2004.06.021 - DOI - PubMed
    1. Biastre K., Burnakis T. (2009). Trospium chloride treatment of overactive bladder. Ann. Pharmacother. 43, 283–295 - PubMed

LinkOut - more resources