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. 2011 Sep 7;133(35):13864-7.
doi: 10.1021/ja206572w. Epub 2011 Aug 16.

Pd(II)-catalyzed para-selective C-H arylation of monosubstituted arenes

Xisheng Wang  1 , Dasheng Leow, Jin-Quan Yu
Affiliations

Pd(II)-catalyzed para-selective C-H arylation of monosubstituted arenes

Xisheng Wang et al. J Am Chem Soc. .

Abstract

Pd-catalyzed highly para-selective C-H arylation of monosubstituted arenes (including toluene) is developed for the first time using an F(+) reagent as a bystanding oxidant. This finding provides a new retrosynthetic disconnection for para-substituted biaryl synthesis via C-H/C-H cross-coupling.

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