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Review
. 2011 Dec;13(14-15):1156-67.
doi: 10.1016/j.micinf.2011.07.007. Epub 2011 Jul 28.

The role of microRNAs in Epstein-Barr virus latency and lytic reactivation

Eleonora Forte  1 , Micah A Luftig
Affiliations
Review

The role of microRNAs in Epstein-Barr virus latency and lytic reactivation

Eleonora Forte et al. Microbes Infect. 2011 Dec.

Abstract

Oncogenic viruses reprogram host gene expression driving proliferation, ensuring survival, and evading the immune response. The recent appreciation of microRNAs (miRNAs) as small non-coding RNAs that broadly regulate gene expression has provided new insight into this complex scheme of host control. This review highlights the role of viral and cellular miRNAs during the latent and lytic phases of the EBV life cycle.

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Figures

Figure 1
Figure 1. Summary of cellular (top) and EBV (bottom) miRNA functions and targets in EBV latency and reactivation
The names above inhibitory arrows are targets of the given miRNA (e.g. miR-BHRF1-3 and CXCL-11). Question marks indicate unknown mechanisms of action or speculative activities (such as the EBV miRNAs suppressing apoptosis during lytic reactivation). These interactions are largely derived from work in B cells, although they may be true in epithelial cells as well (e.g. miR-200 family and ZEB interaction, miR-BART5 and PUMA interaction, and miR-155 and BMP interaction).
See this image and copyright information in PMC

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