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Comment
. 2011 Aug 23;108(34):13883-4.
doi: 10.1073/pnas.1110844108. Epub 2011 Aug 11.

Neuropeptides go the distance for circadian synchrony

G Mark Freeman Jr  1 , Erik D Herzog
Affiliations
Comment

Neuropeptides go the distance for circadian synchrony

G Mark Freeman Jr et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Multiple signals contribute to drive and maintain circadian rhythmicity. (A) As described by Maywood et al. (2), a unique coculture system reveals how neuropeptides released by neurons within a circadian SCN graft can diffuse and restore daily rhythms to an arrhythmic host SCN. Three neuropeptides endogenous to the SCN differ in their potency as paracrine coordinators of circadian rhythms. (B) VIP signaling through its receptor, VPAC2, and Gαs dominates, whereas AVP and GRP can partially compensate for the loss of VIP signaling to sustain synchronous circadian rhythms in gene expression across the SCN.
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References

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