2-{1-[2,8-Bis(trifluoro-meth-yl)quinolin-4-yl]-3,5,6,7,8,8a-hexa-hydro-1H-1,3-oxazolo[3,4-a]pyridin-3-yl}phenol

Abstract

In the title mefloquine-oxazolidine derivative, C(24)H(20)F(6)N(2)O(2), the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair conformation. The oxazoline and benzene residues lie away from the C(6) ring of the quinoline group and, to a first approximation, to one side of the plane through the ten atoms (r.m.s. deviation = 0.025 Å). An intra-molecular O-H⋯N(piperidine) hydrogen bond is present. The crystal packing features C-H⋯O, C-H⋯F and C-H⋯π(hy-droxy-benzene) inter-actions.

Fig. 1.

The molecular structure of (I) showing displacement ellipsoids at the 50% probability level.

Fig. 2.

A view in projection down the c axis of the unit-cell contents of (I) with the C—H···O, C—H···F and C—H···π(hydroxybenzene) interactions shown as orange blue and purple dashed lines, respectively.