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. 2011 Aug;20 Suppl 3(Suppl 3):383-9.
doi: 10.1007/s00586-011-1915-2. Epub 2011 Aug 12.

The IL-1β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation

J Paz Aparicio  1 , I Fernández Bances, E López-Anglada Fernández, A H Montes, A Paz Aparicio, J Pena Vázquez, S Ramos García, S Antón García, P López Fernández, E Valle-Garay, V Asensi
Affiliations

The IL-1β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation

J Paz Aparicio et al. Eur Spine J. 2011 Aug.

Abstract

Purpose: To determine whether polymorphisms (SNPs) in the genes encoding cytokines and nitric oxide synthase (NOS) might play some role in lumbar disc herniation (LDH).

Patients and methods: Case-control study in which 179 patients were retrospectively reviewed. The case group was made of 50 patients with symptomatic LDH diagnosed by MRI while the control group was made of 129 individuals undergoing routine hip or knee arthroplasty with a lifetime lack of low back pain. SNPs in the cytokine genes of IL-1 [IL-1α (-889 C/T), IL-1β (+3953 T/C)], TNF-α (-308 G/A and -238 G/A) and NOS genes [eNOS (r 27 bp, intron 4 and -786 T/C) and iNOS (22 G/A)].

Results: The CC genotype and C allele of the IL-1β (+3953 T/C) SNP were significantly more frequent among LDH patients compared to controls. On the other hand, eNOS (-768 T/C) and iNOS (22 G/A) SNPs were significantly more common in the control group.

Conclusions: Carriers of the CC genotype of the IL-1β (+3953 T/C) SNP were more frequent among LDH patients suggesting some potential role of the IL-1β SNP on LDH pathogenesis. The eNOS (-786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH. Genotyping these SNPs could be useful to identify persons with an increased lifetime risk of disc herniation in whom measures to avoid LDH could be implemented.

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References

    1. Mok FPS, Samartzis D, Karppinen J, Luk KDK, Fong DYT, Cheung KMC. Prevalence, determinants, and association of Schmorl nodes of the lumbar spine with disc degeneration. A population-based study of 2449 individuals. Spine. 2010;35:1944–1952. doi: 10.1097/BRS.0b013e3181d534f3. - DOI - PubMed
    1. Arana E, Royuela A, Kovacs FM, Estremera A, Sarasibar H, Amengual G, Galarraga I, Martinez C, Muriel A, Abraira V, Gil Del Real MT, Zamora J, Campillo C. Lumbar spine: agreement in the interpretation of 1.5-T MR images by using the Nordic Modic Consensus Group classification form. Radiology. 2010;254:809–817. doi: 10.1148/radiol.09090706. - DOI - PubMed
    1. Tong HC, Carson JT, Haig AJ, Quint DJ, Phalke VR, Yamakawa KSJ, Miner JA. Magnetic resonance imaging of the lumbar spine in asymptomatic older adults. J Back Musculoskeletal Rehabil. 2006;19:67–72.
    1. Azpeitia AJ, Martinez SM, Céspedes MM, Rebolledo VM, Millan JJM. Tomografía computarizada de las hernias discales foraminales y extraforaminales. Radiología. 1992;34:345–349.
    1. McGregor AJ, Andrew T, Sambrook PN, Spector TD. Structural, psychological and genetic influences on low back and neck pain: a study of adult female twins. Arthritis Rheum. 2004;51:160–167. doi: 10.1002/art.20236. - DOI - PubMed

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