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Case Reports
. 2011 Nov;63(5):394-7.
doi: 10.1016/j.jinf.2011.08.002. Epub 2011 Aug 9.

Norovirus gastroenteritis successfully treated with nitazoxanide

Danish M Siddiq  1 , Hoonmo L Koo, Javier A Adachi, George M Viola
Affiliations
Case Reports

Norovirus gastroenteritis successfully treated with nitazoxanide

Danish M Siddiq et al. J Infect. 2011 Nov.

Abstract

Infectious diarrhea is a common occurrence in the immunosuppressed population. We present a 43-year-old individual with large-volume stool output Norovirus acute gastroenteritis in the setting of relapsed refractory acute myelogenous leukemia, hematopoietic stem cell transplantation, and biopsy-proven cutaneous and pulmonary graft-versus-host disease. Therapeutic options such as intravenous immunoglobulin or reduction of immunosuppressants were not a feasible choice. A prompt clinical cure was achieved with nitazoxanide, a broad-spectrum antimicrobial agent. Nitazoxanide may be a safe therapeutic alternative, in which a reduction in immunosuppression may not be a viable option.

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