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Comment
. 2011 Aug 16;20(2):133-4.
doi: 10.1016/j.ccr.2011.08.003.

Posterior fossa ependymomas: a tale of two subtypes

Tenley C Archer  1 , Scott L Pomeroy
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Free article
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Posterior fossa ependymomas: a tale of two subtypes

Tenley C Archer et al. Cancer Cell. .
Free article

Abstract

Ependymomas are common childhood brain tumors, but little is known about their underlying biology. In this issue of Cancer Cell, Witt et al. present that posterior fossa ependymomas comprise two distinct molecular subtypes, each with unique gene expression signatures, different levels of genomic instability, and different prognosis.

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  • Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.
    Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T, Weiss WA, Gupta N, Grajkowska W, Lach B, Cho YJ, von Deimling A, Kulozik AE, Witt O, Bader GD, Hawkins CE, Tabori U, Guha A, Rutka JT, Lichter P, Korshunov A, Taylor MD, Pfister SM. Witt H, et al. Cancer Cell. 2011 Aug 16;20(2):143-57. doi: 10.1016/j.ccr.2011.07.007. Cancer Cell. 2011. PMID: 21840481 Free PMC article.

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