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. 2011 Aug 16;20(2):135-6.
doi: 10.1016/j.ccr.2011.08.001.

Surprise! HSC are aberrant in chronic lymphocytic leukemia

Ash A Alizadeh  1 , Ravindra Majeti
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Surprise! HSC are aberrant in chronic lymphocytic leukemia

Ash A Alizadeh et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Kikushige et al. report the surprising finding that, in human chronic lymphocytic leukemia (CLL), hematopoietic stem cells (HSC) aberrantly generate clonal B cells with CLL-like phenotypes, which implicate HSC in the pathogenesis of this mature lymphoid malignancy and has major implications for CLL therapies.

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