doi: 10.1016/j.bmcl.2011.07.070.
Epub 2011 Jul 26.
A novel macrocyclic lactone with insecticidal bioactivity from Streptomyces microflavus neau3
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- PMID: 21840717
- DOI: 10.1016/j.bmcl.2011.07.070
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A novel macrocyclic lactone with insecticidal bioactivity from Streptomyces microflavus neau3
Bioorg Med Chem Lett.
.
Abstract
A novel macrocyclic lactone (1) was isolated from the fermentation broth of Streptomycesmicroflavus neau3, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed high acaricidal activity against adult mites (IC(50)=11.1 μg mL(-1)), and nematocidal activity against Caenorhabditis elegans (IC(50)=17.4 μg mL(-1)), especially the acaricidal activity against mite eggs with an IC(50) of 37.1 μg mL(-1), which was relative higher than that of the commercial acaricide and nematocide milbemycins A(3)/A(4).
Copyright © 2011 Elsevier Ltd. All rights reserved.
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