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. 2011 Aug 14;14(9):1115-7.
doi: 10.1038/nn.2891.

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Quan Lin  1 , Wei Wei, Carlos M Coelho, Xiang Li, Danay Baker-Andresen, Kevin Dudley, Vikram S Ratnu, Zoran Boskovic, Michael S Kobor, Yi E Sun, Timothy W Bredy
Affiliations
Free article

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Quan Lin et al. Nat Neurosci. .
Free article

Abstract

MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.

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