Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Nov;66(4):313-9.
doi: 10.1007/s11130-011-0250-4.

Seasonal variation of phenolic antioxidant-mediated α-glucosidase inhibition of Ascophyllum nodosum

Affiliations

Seasonal variation of phenolic antioxidant-mediated α-glucosidase inhibition of Ascophyllum nodosum

Emmanouil Apostolidis et al. Plant Foods Hum Nutr. 2011 Nov.

Abstract

Ascophyllum nodosum is a brown seaweed that grows abundantly in the US Northeast coastal region. This study examined the seasonal variation of A. nodosum in phenolic contents and subsequent antioxidant, α-glucosidase and α-amylase inhibitory activities. A. nodosum was harvested monthly and extracted in hot water and the resulting extracts were spray-dried. The results indicate a clear seasonal variation in terms of phenolic content, with June and July being the highest (36.4 and 37 mg/g, respectively) and May the lowest (21.8 mg/g). The antioxidant activities, in terms of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, correlated with the phenolic contents observed (r = 0.81), with the month of July being the highest (58%) and April the lowest (26%). Similarly in terms of Trolox equivalent, July had the highest activity (15.53 μM) and April and May the lowest (8.40 and 8.27 μM, respectively). α-glucosidase inhibitory activity exhibited a pattern similar to the phenolic contents observed with July having the highest inhibitory activity (IC(70) 2.23 μg) and April the lowest (IC(70) 26.13 μg), resulting in an inverse correlation between IC(70) values and total phenolic content (r = -0.89). Such seasonal variation is believed to be caused by temperature-related stress considering that A. nodosum is a cold water species.

PubMed Disclaimer

References

    1. Trends Plant Sci. 2006 Apr;11(4):165-6 - PubMed
    1. J Chem Ecol. 2004 Sep;30(9):1693-711 - PubMed
    1. Plant Foods Hum Nutr. 2008 Dec;63(4):163-9 - PubMed
    1. Planta Med. 2009 Feb;75(3):286-92 - PubMed
    1. Can J Physiol Pharmacol. 2007 Nov;85(11):1116-23 - PubMed

MeSH terms

LinkOut - more resources