Covalent coercion by Legionella pneumophila
- PMID: 21843863
- DOI: 10.1016/j.chom.2011.08.002
Covalent coercion by Legionella pneumophila
Abstract
Adenylylation of Rab proteins appears to be an intriguing mechanism that Legionella pneumophila uses to modulate their activity during infection. Now the reverse reaction (deadenylylation) (Neunuebel et al., 2011; Tan and Luo, 2011) and a new posttranslational modification (phosphocholination) of Rab1 (Mukherjee et al., 2011) have been reported.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila.Science. 2011 Jul 22;333(6041):453-6. doi: 10.1126/science.1207193. Epub 2011 Jun 16. Science. 2011. PMID: 21680813 Free PMC article.
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Legionella pneumophila SidD is a deAMPylase that modifies Rab1.Nature. 2011 Jul 6;475(7357):506-9. doi: 10.1038/nature10307. Nature. 2011. PMID: 21734656 Free PMC article.
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Modulation of Rab GTPase function by a protein phosphocholine transferase.Nature. 2011 Aug 7;477(7362):103-6. doi: 10.1038/nature10335. Nature. 2011. PMID: 21822290 Free PMC article.
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